Pfizer Inc. is a large research-based pharmaceutical and biomedical company. As an American multinational firm, it researches and develops medicines and vaccines for immunology, oncology, cardiology, endocrinology and neurology. The company was established in 1849 in New York by two German businessmen, Charles Pfizer and Charles F. Erhart. Pfizer Inc. is headquartered in New York City and has appeared in the top 50 companies on the Forbes Global 2000 list.